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An Open-and-Shut Case With Ion Channels (1 of 2)

Caption: This shows channel closure, intracellular view; Only the protein is shown. It shows VSD helices S1–S3a, green; VSD helices S3b–S4 (“paddle”), red; VSD–pore (S4–S5) linker helix, orange; pore domain, white; Pro405–Val406– Pro407 (“PVP motif”) pore constriction, blue. This video relates to a paper that appeared in the April 13, 2012, issue of Science, published by AAAS. The paper, by M.Ø. Jensen at D. E. Shaw Research in New York, NY, and colleagues was titled, “Mechanism of Voltage Gating in Potassium Channels.”

Credit: Video courtesy of D.D. Shaw Research

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