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An Open-and-Shut Case With Ion Channels (2 of 2)

Caption: This shows VSD–pore domain relative movement (this T1− trajectory is aligned on pore Cα atoms) as S4 translates inwards (down), side view; only one VSD–pore subunit is shown. VSD basic and acidic side chains, and Phe233, are explicitly shown. VSD helices S1–S3a, green; VSD helices S3b–S4 (“paddle”), red; VSD– pore (S4–S5) linker helix, orange; pore domain, white; Pro405–Val406–Pro407 (“PVP motif”) pore constriction, blue. This video relates to a paper that appeared in the April 13, 2012, issue of Science, published by AAAS. The paper, by M.Ø. Jensen at D. E. Shaw Research in New York, NY, and colleagues was titled, “Mechanism of Voltage Gating in Potassium Channels.”

Credit: Video courtesy of D.D. Shaw Research

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