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Stem Cells Offer Clues to Heart Disease

Caption: This picture shows an enlarged view of a single induced pluripotent stem cell-derived cardiomyocyte derived from a healthy individual (top left) and from a patient with familial dilated cardiomyopathy (bottom left). Upon exposure to the catecholamine drug norepinephrine, there is marked degeneration of cellular integrity in cardiac cell from the diseased patient (bottom right), which was not seen in cardiac cell from the healthy individual (top right). This image relates to a paper that appeared in the April 18, 2012, issue of Science Translational Medicine, published by AAAS. The paper, by Dr. N. Sun at Stanford University School of Medicine in Stanford, Calif., and colleagues was titled, "Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy."

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