![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
|
Contact: Mazahir Hasan
Mazahir.Hasan@mpimf-heidelberg.mpg.de
Public Library of Science
Caption: Activators (green) bind to DNA sequences (blue) and turn-on gene expression (arrow, upper panel) in young mice. Under these conditions gene expression continues to remain active in adult mice (right, upper panel). On the other hand, unavailability of the activator in young mice turns-off gene expression (left, lower panel), which subsequently leads to changes in gene accessibility (blue, lower right panel), thus disabling activator-to-DNA binding (lower right panel) with gene expression remaining switched-off.
Credit: Zhu et al.
Usage Restrictions: None
Related news release: Turn-ons and turn-offs for neurons
|