Contact: Morgan Kelly
Caption: In a healthy neuron (left), mitochondria are carried along by motor proteins dynein and kinesin-1. Viral infection (right) floods the cell with calcium (Ca2+), which, when detected by the mitochondrial protein Miro, brings mitochondria to a halt and causes them to shed motor proteins. The Princeton researchers suggest that the virus then co-opts kinesin-1 to freely move within the infected cell and spread into the nervous system. The research presents a possible explanation for how other neurotropic viruses such as rabies, West Nile and polio also attack and disrupt the nervous system.
Credit: Tal Kramer
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