Contact: Margaret Allen
Southern Methodist University
Caption: SMU biologists Pia Vogel and John Wise are using the computational power of SMU's high-performance supercomputer to screen millions of drug compounds in hopes of finding one that will aid in the fight against recurring cancer. Wise has deduced what is believed to be the first dynamic model of the human P-glycoprotein, known for its ability to pump out chemotherapy from a cancer cell, allowing the cell to survive. Using the dynamic model, Wise and Vogel have found some compounds that "bind" to the protein. This provides hope they can find a compound that will throw a wrench into the cell's ability to pump out cancer-killing chemotherapy by disabling the energy source that powers the pump. Video summary, http://bit.ly/MeUFOo.
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