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Contact: Mika Ono
Scripps Research Institute

Allosteric Machines

Caption: More than 50 percent of therapeutic drugs target GPCRs, including allergy and heart medication, drugs that target the central nervous system, and anti-depressants. Based on scientists' emerging understanding of GPCRs, this image represents GPCRs as complex machines, controlled not only by their pharmacological ligands, but also by sodium, cholesterol, lipids, and water.

Credit: Image by Yekaterina Kadyshevskaya, GPCR Network, The Scripps Research Institute

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