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Brain-Penetrating Nanoparticles (1 of 3)

Caption: This image shows real-time imaging of nanoparticles (green) coated with polyethylene-glycol (PEG), a hydrophilic, non-toxic polymer, which penetrate within a normal rodent brain. Without the PEG coating, negatively charged, hydrophobic particles (red) of a similar size do not penetrate. This image relates to a paper that appeared in the Aug. 29, 2012, issue of Science Translational Medicine, published by AAAS. The paper, by Dr. E.A. Nance at Johns Hopkins University School of Medicine in Baltimore, Md., and colleagues, was titled, "A Dense Poly(Ethylene Glycol) Coating Improves Penetration of Large Polymeric Nanoparticles Within Brain Tissue."

Credit: Elizabeth Nance, Graeme Woodworth, Kurt Sailor

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