Contact: Nicole Rura
Whitehead Institute for Biomedical Research
Caption: In this image of mouse embryonic fibroblasts undergoing reprogramming, each colored dot represents messenger RNA associated with a specific gene that is active in cells being reprogrammed. Red dots represent mRNA for the gene Sall4, green is Sox2, and blue is Fbxo15. The researchers determined that Sox2 activates Sall4 and then activates the downstream gene Fbxo15, creating a gene hierarchy in the later phase of reprogramming.
Credit: Dina Faddah/Whitehead Institute
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