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Contact: Rita Sullivan King
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Rockefeller University Press

CFTR Functionality

Caption: A new JGP study provided evidence about the functionality of CFTR, a protein that plays a critical role in cystic fibrosis. Here, an updated model illustrates the relationship between an opening/closing cycle of the gate and ATP consumption in CFTR’s nucleotide-binding domains.

Credit: Jih, K.-Y., et al. 2012. J. Gen. Physiol. 140:347–359.

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Related news release: New insights into functionality of cystic fibrosis protein


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