Contact: Elisabeth (Lisa) Lyons
Caption: This is a direct observation of neuronal reprogramming of PDGFR-sorted pericyte-derived cells from the adult human brain by continuous live imaging in culture. Note the change in morphology of a cell coexpressing Sox2 and Mash1 (blue arrow) during reprogramming. Postimaging immunocytochemistry for III-tubulin (white) confirms the neuronal identity of the reprogrammed cell at the end of live imaging.
Credit: Cell Stem Cell, a Cell Press Journal, Karow et al.
Usage Restrictions: Under embargo until 12 Noon ET on October 4, 2012. Please use proper credit.
Related news release: New human neurons from adult cells right there in the brain