Contact: Aaron Dubrow
University of Texas at Austin, Texas Advanced Computing Center
Caption: Top: Models showing different lesions wedged between DNA bases. Lesions that are more easily repaired, like the one marked in the image, are more likely to be removed before they can create mutations in replicated DNA. Bottom:The stacking interactions between lesions and adjacent DNA base pairs stabilize DNA. Dibenzo [a,l] pyrene derived lesions (featured on the top and bottom right) have a great number of interactions, making them especially difficult to remove.
Credit: New York University
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Related news release: Cancer bound