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Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Molecular Mechanisms Underlying Stem Cell Reprogramming

Caption: At the beginning of cellular reprogramming, gene regulatory proteins Oct 4 (O), Sox2 (S) and Klf4 (K) enter the chromosomes at silent genes and allow c-Myc (M) binding. However, there are large chromosomal domains that contain particular epigenetic marks (red triangles) that prevent O, S, K, M from binding. Erasing the marks allows the regulatory proteins to bind and promotes the process of cellular reprogramming.

Credit: Kenneth Zaret, PhD, at the Perelman School of Medicine, University of Pennsylvania

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