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Single Protein Restricts a Deadly Salmonella Variant to Humans (1 of 1)

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Caption: The animated model represents Salmonella Typhi infecting a mouse (left) or a human (right) macrophage. In the mouse macrophage a Rab32-dependent transport pathway eliminates S. Typhi by delivering an anti-microbial activity (depicted as a bomb). In the human macrophage S. Typhi survives and replicates, which is likely due to differences between mouse and human Rab32. This image relates to a paper that appeared in the Nov. 16, 2012, issue of Science, published by AAAS. The paper, by Stefania SpanÚ and Jorge GalŠn at Yale University School of Medicine in New Haven, Conn. was titled, "A Rab32-Dependent Pathway Contributes to Salmonella Typhi Host Restriction."

Credit: Video courtesy of Stefania SpanÚ and Jorge GalŠn

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