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DNA Repair

Caption: A computer simulation of Ape1, a DNA-repair protein, binding to a strand of DNA. DNA strands are in yellow and green, the protein is in blue, and ultraviolet-absorbing amino acids are in red. The results from the simulation are being used to determine how specific differences in the Ape1 protein that have been found in a portion of the human population affect the DNA repair capacity of those individuals. Such knowledge will help researchers predict which people are at greater risk of developing disease from environmental exposures that induce the formation of abasic lesions.

Credit: Courtesy of Lawrence Livermore National Laboratory.

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