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X-Ray Laser Pulses Reveal Key Parasite Enzyme (1 of 15)

Caption: Scanning electron micrograph of a SF9 insect cell containing an in vivo grown Trypanosoma brucei cathepsin B microcrystal that spikes out of the cell membrane. In vivo crystal growth occurs spontaneously within the Baculovirus-infected cell during overexpression of the recombinant protein. After disruption of the cell, the crystals could be easily isolated by centrifugation steps. This image relates to a paper that appeared in the Nov. 29, 2012, issue of Science Express, published by AAAS. The paper, by Lars Redecke at the University of Hamburg in Hamburg, Germany, and colleagues was titled, "Natively Inhibited Trypanosoma brucei Cathepsin B Structure Determined Using an X-ray Laser."

Credit: Image courtesy of Michael Duszenko, University of Tübingen

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