Contact: Mary Beth O'Leary
Caption: This zebrafish embryo developed a limb that looks more like a leg than a fin, after being engineered to produce the HoxD13 protein within the cells at the tip of the developing fin. Changes in HoxD13 production likely contributed to the transition from fin to leg development, during animal evolution.
Credit: Freitas et al., Developmental Cell
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Related news release: From fish to man: Research reveals how fins became legs