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Neural Stem Cell Transplants in ALS

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Caption: This SOD1G93A mouse, transplanted at 55 days of age with human neural stem cells (hNSCs) (using the four-site protocol described in the paper in which key life-sustaining regions of the spinal cord were targeted by very migratory hNSCs that protect the mouse's own motor neurons), meets criterion on the rotarod at 205 days of age, whereas untreated affected littermates or littermates treated with control cells have succumbed by 125 days. In other words, these animals are performing motor tasks while untreated age-matched animals are not even alive. Meeting rotarod criteria beyond that time point of 125 days (in this series - i.e. baseline lifespan) represents "motor symptom-free survival", an important interval because it represents more than just survival, it indicates living with residual function. This video relates to a paper that appeared in the Dec. 19, 2012, issue of Science Translational Medicine, published by AAAS. The paper, by Y.D. Teng at Harvard Medical School in Boston, Mass., and colleagues was titled, "Multimodal Actions of Neural Stem Cells in a Mouse Model of ALS: A Meta-Analysis."

Credit: Video courtesy of Evan Y. Snyder, Yang D. Teng, & Robert H. Brown, Jr.

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