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Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Mimicking a Natural Defense Against Malaria

Caption: Transmission electron micrograph images reveal lysis of the parasite digestive vacuole (DV) upon treatment with human PF4 (top right), or the small molecules PMX207 and PMX1207 (bottom) as shown by the dispersal of hemozoin fragments throughout the cytoplasm (red arrowheads) and undigested hemoglobin-containing vesicles (yellow arrowheads). Mock-treated control (top left) shows complete integrity of the DV membrane (white arrowheads), encapsulating all hemozoin crystals. (N: parasite nucleus).

Credit: Melanie G. Millholland and Doron C. Greenbaum, Perelman School of Medicine, University of Pennsylvania

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Related news release: Penn team mimicking a natural defense against malaria to develop new treatments

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