Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Metformin Works in Different Way than Previously Thought

Caption: Proposed model: Metformin enters the cell and acts on the mitochondria, causing increased AMP. Elevated cellular AMP levels inhibit membrane bound adenylyl cyclase, causing a reduction in cellular cAMP levels and decreased PKA activation and target phosphorylation.

Credit: Morris Birnbaum, M.D., Ph.D., Perelman School of Medicine, University of Pennsylvania; Nature

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