Contact: Karen Kreeger
University of Pennsylvania School of Medicine
Caption: Proposed model: Metformin enters the cell and acts on the mitochondria, causing increased AMP. Elevated cellular AMP levels inhibit membrane bound adenylyl cyclase, causing a reduction in cellular cAMP levels and decreased PKA activation and target phosphorylation.
Credit: Morris Birnbaum, M.D., Ph.D., Perelman School of Medicine, University of Pennsylvania; Nature
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