Contact: Lise Grandperrin
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Figure 6. Model of a Neuronal Conduction of Excitation Without Action Potentials

Caption: Activation of neutral sphingomyelinase triggers ceramide production in rafts then the release of calcium from intracellular stores which activates the NO-cGMP pathway. This pathway activates downstream sphingomyelinase in neighbouring rafts which ensures the propagation of the excitation. L-Arg: L-arginine, NOS: NO synthase, GC: guanylate cyclase, nSmase: neutral sphingomyelinase.

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Related news release: Neuronal conduction of excitation without action potentials based on ceramide production