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Contact: David Sampson
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Elsevier Health Sciences

Different Views of a Dystrophic Mouse during the Wire Test

Caption: The mice were allowed to grasp a metal wire maintained horizontally above a thick layer of soft bedding (upper left). After exploring the wire for a short period of time (upper right), the mice tried to pull themselves on the wire (bottom left), a very energy-demanding exercise, until they lost grip of their hind paws and hung onto the wire with their forelimbs only (bottom right). From this position, the untreated mdx5Cv mice were unable to sustain their own body weight for more than a few seconds before falling, whereas the mdx5Cv mice treated with tamoxifen (not shown) performed much better and as well as normal mice.

Credit: Dorchies et al.

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Related news release: Tamoxifen ameliorates symptoms of Duchenne muscular dystrophy


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