2 States of TFIID (image) DOE/Lawrence Berkeley National Laboratory Caption The TFIID transcription factor protein co-exists in two states: Canonical, in which the lobe A is connected to the lobe C; and rearranged, in which the lobe A is connected to the lobe B. Only in the rearranged state does TFIID bind to DNA. Credit (Image courtesy of Nogales Lab) Usage Restrictions None Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.