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Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst

Tension Stabilizes Bioriented Attachments

Caption: This shows the expression of the chromokinesin NOD (red) stabilizes aberrant interactions between kinetochores and spindle microtubules (green). Tension stabilizes bioriented attachments where each sister chromatid is attached to microtubules from opposite spindle poles while tensionless attachments are typically unstable and corrected. Elevating the polar ejection force that pushes chromosome arms away from spindle poles overwhelms error correction, resulting in a dose-dependent stabilization of syntelic attachments where sister chromatids are attached to the same spindle pole.

Credit: Thomas Maresca, UMass AMherst

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