Contact: Rita Sullivan King
Rockefeller University Press
Caption: A JCB study reveals that a neuronal protein linked to neurodevelopmental disorders suppresses the development of inhibitory synapses. MDGA1 disrupts the interaction between neuroligin-2 and neurexin-1, two synaptic cell adhesion molecules associated with autism and schizophrenia that promote inhibitory synapse development. In this co-culture assay, a neuron forms multiple presynapses (red) with a COS7 cell (right) expressing neuroligin-2 (blue) but only a few presynapses with a cell (left) coexpressing neuroligin-2 and MDGA1 (green).
Credit: Pettem, K.L., et al. 2013. J. Cell Biol. doi:10.1083/jcb.201206028
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Related news release: Protein family linked to autism suppresses the development of inhibitory synapses