[ Back to EurekAlert! ]

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press

MDGA1 Suppresses Neuronal Synaptogenesis

Caption: A JCB study reveals that a neuronal protein linked to neurodevelopmental disorders suppresses the development of inhibitory synapses. MDGA1 disrupts the interaction between neuroligin-2 and neurexin-1, two synaptic cell adhesion molecules associated with autism and schizophrenia that promote inhibitory synapse development. In this co-culture assay, a neuron forms multiple presynapses (red) with a COS7 cell (right) expressing neuroligin-2 (blue) but only a few presynapses with a cell (left) coexpressing neuroligin-2 and MDGA1 (green).

Credit: Pettem, K.L., et al. 2013. J. Cell Biol. doi:10.1083/jcb.201206028

Usage Restrictions: Reporters may freely use these materials in news coverage, with the appropriate credit information.

Related news release: Protein family linked to autism suppresses the development of inhibitory synapses


[ Back to EurekAlert! ]