Contact: Gail Gallessich
University of California - Santa Barbara
Caption: This shows a summary of cocaine-seeking behavior (lever-presses) during 30 minute sessions conducted on Days 3 and 4 of withdrawal (Test1 and 2, respectively) from daily high amounts of IV cocaine. When tested across days, vehicle-induced (VEH) controls exhibit a reduction in cocaine-seeking, indicating extinction. In contrast, rats infused intracranially into the ventromedial prefrontal cortex (vmPFC) with antagonists for mGluR5 (MTEP PreRx) or mGluR1 (JNJ PreRx) prior to Test 1 failed to show this learning. Similarly, rats injected intracranially with the mGluR1 blocker following Test 1 (to influence memory consolidation processes) also failed to exhibit learning. These data indicate that mimicking a cocaine-induced deficit in mGluR1/5 function within this frontal cortical region results in persistent cocaine-seeking behavior, reflecting a deficit in learning and memory processes.
Credit: University of California - Santa Barbara
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