Contact: Katie Marquedant
Massachusetts General Hospital
Caption: Medulloblastoma cells secrete the developmental protein Shh, which binds to receptors in stromal cells and triggers signaling that leads to the production of PlGF. Stromal-derived PlGF then binds to Nrp1 receptors in the cancer cell and conveys signals that sustain the growth and spread of the tumor.
Credit: Lance Munn, Ph.D., and Nathaniel Kirkpatrick, Ph.D., Steele Laboratory for Tumor Biology, Massachusetts General Hospital.
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