Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Disease-Causing Proteins in Brain Disorders

Caption: This shows the wing posture in a normal fly and a fly with hnRNPA2 mutation. The mutant fly is weak and unable to maintain normal wing posture. Muscle histology shows that hnRNPA2 is nuclear in normal flies, but accumulates in innumerable cytoplasmic aggregates in flies with the hnRNPA2 mutation.

Credit: Nam Chul Kim, St. Jude Children’s Research Hospital; Nature

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