Contact: Rex Graham
ragraham@ucsd.edu
858-822-3075
University of California - San Diego

Subnetwork Enriched for the Hallmarks of Cancer

Caption: Example discriminative subnetworks from van de Vijver et al. are shown in (a-e), while those from Wang et al. are shown in (f-k). Nodes and links represent human proteins and protein interactions, respectively. The color of each node scales with the change in expression of the corresponding gene for metastatic versus nonmetastatic cancer. The shape of each node indicates whether its gene is significantly differentially-expressed (diamond; p < 0.05 from a two-tailed t-test) or not (circle). The predominant cellular functions from are indicated next to each module. Known breast cancer susceptibility genes are marked by a blue asterisk. This is figure 1 from a Molecular Systems Biology published online Oct. 16, 2007. Senior author: Trey Ideker from UC San Diego.

Credit: Trey Ideker / UC San Diego / Molecular Systems Biology

Usage Restrictions: Mandatory credit: Trey Ideker / UC San Diego / Molecular Systems Biology

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