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Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center

How the Anticancer Drug AS1411 Alters MicroRNA Levels

Caption: The drug AS1411 works by blocking the cell's production of regulatory molecules called microRNA, some types of which are associated with cancer. Specifically, the drug inhibits a protein called nucleolin that plays a critical role in the microRNA maturation process. Left: Steps in the microRNA maturation process. Right: How AS1411 interferes with microRNA maturation.

Credit: The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute

Usage Restrictions: Please credit The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute

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