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Contact: Jules Asher
NIH/National Institute of Mental Health

CD33 and Beta-Amyloid in Control and Knockout Mice

Caption: Activity of a regulator protein called CD33 (green) clogs removal of brain-damaging debris, beta-amyloid protein (red), by support cells, microglia. Microglia of normal control mice (A") show more CD33 and less beta-amyloid than mice in which CD33 expression is experimentally knocked-out (B").

Credit: Rudolph Tanzi, Ph.D., of Massachusetts General Hospital and Harvard University

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