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Contact: Jules Asher
NIMHpress@nih.gov
301-443-4536
NIH/National Institute of Mental Health

CD33 Over-Expressed or Inactivated and Beta-Amyloid

Caption: Little beta-amyloid can be seen in microglia of a mouse line in which CD33 is over-expressed (C"), compared to microglia of mice in which CD33 is experimentally inactivated (D"). Evidence from post-mortem human brains indicates that CD33 is similarly over-active in Alzheimer's disease, suggesting that a treatment that impedes it might help treat or prevent the disease.

Credit: Rudolph Tanzi, Ph.D., of Massachusetts General Hospital and Harvard University

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