Contact: Karen Kreeger
University of Pennsylvania School of Medicine
Caption: Inhibition of Hedgehog signaling in a MEN1 mouse model results in decreased islet cell proliferation. Immunofluorescence for BrdUrd and insulin in pancreas of Men1-excised mice fed with either vehicle control (left) or Erivedge/GDC-0449 (right) for 4 weeks at a dose of 100 mg/kg twice daily.
Credit: Xianxin Hua, MD, PhD, Buddha Gurung, PhD, Perelman School of Medicine, University of Pennsylvania
Usage Restrictions: None
Related news release: Link between inherited endocrine tumor syndrome and much-studied cell pathway