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Contact: Alisa Z Machalek
NIH/National Institute of General Medical Sciences

Dynamin in Action

Caption: Scientists studying dynamin use an artificial membrane (orange) to analyze the protein's action. In the first image, dynamin has squeezed the membrane to create two vesicle-like structures (lower right). In the second image, taken seconds later, dynamin has severed the membrane to release these structures.

Credit: From Ramachandran R*, Pucadyil T.J.*, Liu Y.W., Acharya S., Leonard M., Lukiyanchuk V., Schmid S.L. 2009. Membrane insertion of the pleckstrin homology domain variable loop 1 is critical for dynamin-catalyzed vesicle scission. Mol Biol Cell. 2009 20:4630-9. (* The first two authors contributed equally.)

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