Research Identifies a Way to Make Cancer Cells More Responsive to Chemotherapy (video) University of Western Ontario Share Print E-Mail Loading video... Caption New research from Western University explains why some cancer cells don't respond to chemotherapy, and identifies a mechanism to rectify that. Dr. Shawn Li, Ph.D., explains how a protein called Numb functions to promote the death of cancer cells by binding to and stabilizing a tumor suppressor protein called p53. When Numb is reduced or methylated by an enzyme called Set8, it will no longer protect p53, and the cells become resistant to chemotherapy. Credit Schulich School of Medicine & Dentistry, Western University Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.