Contact: Kathy Wallis
University of Western Ontario
Caption: New research from Western University explains why some cancer cells don't respond to chemotherapy, and identifies a mechanism to rectify that. Dr. Shawn Li, Ph.D., explains how a protein called Numb functions to promote the death of cancer cells by binding to and stabilizing a tumor suppressor protein called p53. When Numb is reduced or methylated by an enzyme called Set8, it will no longer protect p53, and the cells become resistant to chemotherapy.
Credit: Schulich School of Medicine & Dentistry, Western University
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