Modeling Sickle Cell Bloodflow (video) Brown University Loading video... Caption Researchers from Brown University used computer models to show how different types of red blood cells interact to cause sickle cell crisis, a painful blockage of blood flow in capillaries. The models showed that sticky SS2 cells (blue) start the process by getting stuck on blood vessel walls. Rigid, crescent-shaped cells (red) that are the hallmark of the disease then get stuck behind the SS2 cells. This is the first time a biophysical mechanism behind sickle cell disease has been identified. Credit Karniadakis Lab / Brown University Usage Restrictions None Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.