New Candidate Substrates Identified (image) University of Massachusetts at Amherst Caption Caulobacter crescentus (above) generates radically different cell types upon division. The ClpXP protease (illustrated below) recognizes and destroys many protein substrates that allow Caulobacter to differentiate into these different cell types. New work identifying scores of new candidate substrates of ClpXP to reveal how protein degradation is critical to cell cycle progression and bacterial development could lead to new antibiotic targets. Credit Peter Chien, UMass Amherst Usage Restrictions None Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.