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Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst

New Candidate Substrates Identified

Caption: Caulobacter crescentus (above) generates radically different cell types upon division. The ClpXP protease (illustrated below) recognizes and destroys many protein substrates that allow Caulobacter to differentiate into these different cell types. New work identifying scores of new candidate substrates of ClpXP to reveal how protein degradation is critical to cell cycle progression and bacterial development could lead to new antibiotic targets.

Credit: Peter Chien, UMass Amherst

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Related news release: Biochemists identify protease substrates important for bacterial growth and development


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