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Contact: Vanessa Pavinato
European Society for Medical Oncology

Amplification of c-MET: A Study of Resistance to Anti-EGFR Therapies in Colorectal Cancer

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Caption: F. Ciardiello shares his comments on a next generation sequencing study applied to identify genetic alterations in patients with metastatic colorectal cancer who do not develop K-ras mutations during the course of therapy with cetuximab and panitumumab. The analysis revealed a high level of amplification of the MET proto-oncogene. The emergence of MET amplification in circulating, cell-free, DNA may be used to select patients most likely to benefit from anti-MET therapies. http://www.esmo.org

Credit: European Society for Medical Oncology

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