Active and Inactive PTEN (image) Johns Hopkins Medicine Caption PTEN is shown in its active (above) and inactive (below) forms. Phosphate tags (red) on PTEN's tail cause a shape change, which prevents PTEN from binding to the cell's outer envelope (blue) and removing a phosphate from PIP3 (yellow). Credit David Bolduc Usage Restrictions None Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.