Deficiency of a Protein (video) Columbia University Medical Center Loading video... Caption A team of Columbia University Medical Center researchers, led by Nobel laureate Eric R. Kandel, MD, has found that deficiency of a protein called RbAp48 in the hippocampus is a significant contributor to age-related memory loss and that this form of memory loss is reversible. The study, conducted in postmortem human brain cells and in mice, also offers the strongest causal evidence that age-related memory loss and Alzheimer's disease are distinct conditions. The findings were published on August 28 in the online edition of Science Translational Medicine. Credit Columbia University Medical Center Usage Restrictions The video should only be used in the context of coverage of this news story. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.