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Contact: Karin Eskenazi
Columbia University Medical Center

Deficiency of a Protein

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Caption: A team of Columbia University Medical Center researchers, led by Nobel laureate Eric R. Kandel, MD, has found that deficiency of a protein called RbAp48 in the hippocampus is a significant contributor to age-related memory loss and that this form of memory loss is reversible. The study, conducted in postmortem human brain cells and in mice, also offers the strongest causal evidence that age-related memory loss and Alzheimer's disease are distinct conditions. The findings were published on August 28 in the online edition of Science Translational Medicine.

Credit: Columbia University Medical Center

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