A Major Cause of Age-Related Memory Loss Identified (2 of 2) (video) Columbia University Medical Center Share Print E-Mail Loading video... Caption A team of Columbia University Medical Center researchers, led by Nobel laureate Eric R. Kandel, MD, has found that deficiency of a protein called RbAp48 in the hippocampus is a significant contributor to age-related memory loss and that this form of memory loss is reversible. The study, conducted in postmortem human brain cells and in mice, also offers the strongest causal evidence that age-related memory loss and Alzheimer's disease are distinct conditions. The findings were published in the August 28 online edition of Science Translational Medicine. Credit Columbia University Medical Center Usage Restrictions The video may only be used within the context of this news. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.