Contact: Karen Kreeger
University of Pennsylvania School of Medicine
Caption: When comparing gains and losses of two histone modifications, there were large-scale domains of enriched histone modifier "mesas" and depleted histone modifier "canyons," as graphically depicted when comparing the gains and losses. The enriched "mesas" form at lamin B1-associated areas on the chromatin.
Credit: Parisha Shah, PhD; Shelley Berger, PhD, Perelman School of Medicine, University of Pennsylvania; Genes & Development
Usage Restrictions: None
Related news release: Possible links: Epigenetics, aging, nucleus protein mutations to cancer, rare disorders