Bone Hormone Influences Brain Development and Cognition (image) Columbia University Medical Center Share Print E-Mail Caption During pregnancy, the bone hormone osteocalcin is produced by the mother; it crosses the placenta, to reach the fetus, where it promotes the formation of the hippocampus and the development of spatial learning and memory. Postnatally, osteocalcin crosses the blood-brain barrier, to act in various regions of the brain, including the hippocampus, where it causes changes in brain chemistry that help prevent anxiety and depression and improve spatial learning and memory. Credit Gerard Karsenty, MD, PhD and Franck Oury, PhD/Columbia University Medical Center Usage Restrictions The image should only be used in the context of this story. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.