Contact: Jim Fessenden
University of Massachusetts Medical School
Caption: A computer simulation shows the two step process for a condensing chromosome, which happens as the cell moves from interphase to metaphase. In the first phase, chromatin loops of 80,000 to 120,000 DNA base pairs form, radiating out from a scaffold and compacting the chromosome linearly. This is followed by axial compression of the chromosome, much like a spring being compressed, and results in a neat, tightly folded package.
Credit: Illustration CreditsImakaev M, Fudenberg G, Naumova N, Dekker J, and Mirny L.
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