Bioengineers from the University of California, San Diego are leading the research team that has published a breakthrough single-cell genome sequencing technique that stands to improve our understanding of genomic diversity among cells from the same human brain. With the new approach, the researchers generated the most complete genome sequences published thus far from single E. coli cells and individual neurons from the human brain. The approach, called Microwell Displacement Amplification System, confines genome amplification to fluid-filled wells with a volume of just 12 nanoliters. This work is published in the journal Nature Biotechnology on November 10, 2013. An animated video illustrating the technique is available upon request.