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SUMO-1 Gene Rescues Hearts with Broken Plumbing Arms (2 of 3)

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Caption: Co-author Dr. Hajjar narrates this movie, a glimpse into the intracellular space of the cardiomyocyte. The movie shows how SUMO-1 attaches to SERCA2a and increases its activity, leading to faster calcium uptake. This in turn allows faster calcium entry into the sarcoplasmic reticulum. This image relates to a paper that appeared in the November 13, 2013, issue of Science Translational Medicine, published by AAAS. The paper, by Dr. L. Tilemann at Icahn School of Medicine at Mount Sinai in New York, N.Y., and colleagues was titled, "SUMO-1 Gene Transfer Improves Cardiac Function in a Large-Animal Model of Heart Failure."

Credit: Video courtey of Roger J. Hajjar, MD

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