Contact: Kathy Wallis
University of Western Ontario
Caption: The skeleton is constantly being remodelled by the breakdown of old bone by cells called osteoclasts and the formation of new bone by cells called osteoblasts. This coordinated activity is essential for maintaining healthy bone. However, excessive osteoclast activity leads to bone destruction in skeletal diseases such as osteoporosis, rheumatoid arthritis and cancer metastases in bone. Now researchers at Western University (London, Canada) have identified one particular PI3K isoform which offers a potential new approach for the treatment of inflammatory bone diseases and skeletal metastases.
Credit: Schulich School of Medicine & Dentistry, Western University
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