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Contact: Neil Schoenherr
nschoenherr@wustl.edu
314-935-5235
Washington University in St. Louis

Huntington's Disease Curve

Caption: In the figure above, the open circles are data for individual patients with Huntington's disease, and the solid circles are averages for a given CAG repeat length. Huntington's disease is caused by a defect in the huntingtin gene (Htt) that causes an abnormal expansion in the CAG codon or triplet that codes for the amino acid glutamine. This CAG triplet expansion in unrelated genes is the root of at least nine neurodegenerative disorders, including Huntington's disease.

Credit: MacDonald et al., (2003) Neuromolecular Med. 4: 7-20

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