Contact: Karen Kreeger
University of Pennsylvania School of Medicine
Caption: There is increased ER stress in the pancreas of aged mice. Phosphorylation of PERK (P-PERK), indicative of ER stress and activation of the unfolded protein response, is evident in ß-cells. Representative images of P-PERK (green) in B-cells (red) immunostained for insulin in young undisturbed (YC), young SD (YSD), old undisturbed (OC) and old sleep deprived (OSD) mice.
Credit: Nirinjini Naidoo, Ph.D., Division of Sleep Medicine: Perelman School of Medicine; Aging Cell
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